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Structural, Functional and Molecular Impact on the Cardiovascular System in ApoE-/- Mice Exposed to Aerosol from modified risk tobacco products, the Carbon Heated Tobacco Product 1.2 and the Tobacco Heating System 2.2 compared to Cigarette Smoke effects (mRNA data).

ABSTRACT: AIM: To investigate the molecular, structural, and functional impact of aerosols from two heat-not-burn-based MRTPs, the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of cigarette mainstream smoke (CS) on the cardiovascular system of ApoE-/- mice. METHOD: Female ApoE-/- mice were exposed to aerosols from THS 2.2 and CHTP 1.2 or to CS from 3R4F for up to 6 months at matching nicotine concentrations. A cessation and a switching group (3 months exposure to 3R4F CS followed by filtered air or CHTP 1.2 for 3 months) were included. Cardiovascular effects were investigated using echocardiography, histopathology, immunohistochemistry, and transcriptomics. RESULTS: Continuous exposure to aerosols from CHTP 1.2 and THS 2.2 did not affect the atherosclerosis progression, heart function, left ventricular structure and cardiovascular transcriptome. Exposure to CS from 3R4F triggered atherosclerosis progression, reduced systolic ejection fraction and fractional shortening, caused heart left ventricle hypertrophy and initiated significant dysregulation in the transcriptomes of the heart ventricle and thoracic aorta. Importantly, smoking cessation and switching to CHTP 1.2 aerosol similarly improved the structural, functional, and molecular changes caused by 3R4F CS. CONCLUSION: Exposure to aerosols from CHTP 1.2 and THS 2.2 lacked most of the CS exposure-related functional, structural and molecular effects. Smoking cessation or switching to CHTP 1.2 aerosol caused a similar recovery from the 3R4F CS effect in the ApoE-/- model with no further acceleration of plaque progression beyond the aging-related rate.

ORGANISM(S): Mus musculus

SUBMITTER: Justyna Szostak 

PROVIDER: E-MTAB-7980 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Structural, functional, and molecular impact on the cardiovascular system in ApoE<sup>-/-</sup> mice exposed to aerosol from candidate modified risk tobacco products, Carbon Heated Tobacco Product 1.2 and Tobacco Heating System 2.2, compared with cigarette smoke.

Szostak Justyna J   Titz Bjoern B   Schlage Walter K WK   Guedj Emmanuel E   Sewer Alain A   Phillips Blaine B   Leroy Patrice P   Buettner Ansgar A   Neau Laurent L   Trivedi Keyur K   Martin Florian F   Ivanov Nikolai V NV   Vanscheeuwijck Patrick P   Peitsch Manuel C MC   Hoeng Julia J  

Chemico-biological interactions 20191106

<h4>Aim</h4>To investigate the molecular, structural, and functional impact of aerosols from candidate modified risk tobacco products (cMRTP), the Carbon Heated Tobacco Product (CHTP) 1.2 and Tobacco Heating System (THS) 2.2, compared with that of mainstream cigarette smoke (CS) on the cardiovascular system of ApoE<sup>-/-</sup> mice.<h4>Methods</h4>Female ApoE<sup>-/-</sup> mice were exposed to aerosols from THS 2.2 and CHTP 1.2 or to CS from the 3R4F reference cigarette for up to 6 months at m  ...[more]

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