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RNA expression in immortalized lymphocytes of schizophrenia and bipolar disorders patients and their unaffected relatives.

ABSTRACT: RNA expression in immortalized lymphocytes of schizophrenia and bipolar disorders patients were compared to that of their non-affected relatives to identify genes showing significant differences in expression. The study subjects were recruited in the Eastern Quebec kindred study.

ORGANISM(S): Homo sapiens

SUBMITTER: Alexandre Bureau

PROVIDER: E-MTAB-8018 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A multimodal attempt to follow-up linkage regions using RNA expression, SNPs and CpG methylation in schizophrenia and bipolar disorder kindreds.

Chagnon Yvon C YC Maziade Michel M Paccalet Thomas T Croteau Jordie J Fournier Alain A Roy Marc-André MA Bureau Alexandre A

European journal of human genetics : EJHG 20191106 4

The complexity of schizophrenia (SZ) and bipolar disorder (BD) has slowed down progress in understanding their genetic roots. Alternative genomic approaches are needed to bypass these difficulties. We attempted a multimodal approach to follow-up on reported linkage findings in SZ and BD from the Eastern Quebec kindreds in chromosomes 3q21, 4p34, 6p22, 8p21, 8p11, 13q11-q14, 15q13, 16p12, and 18q21. First, in 498 subjects, we measured RNA expression (47 K Illumina chips) in SZ and BD patients tha ...[more]

PMID: 31695175

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