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HNF1A allelic series in derived human beta-like cells from hESCs

ABSTRACT: CRISPR-Cas9 was used to generate HNF1a mutants (+/- and -/-) in human embryonic stem cell lines and used an in vitro differentiation system to study pancreatic beta cell differentiation and subsequent function of the derivative beta cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Fabian Cardenas-Diaz

PROVIDER: E-MTAB-8120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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