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Unknown,Transcriptomics,Genomics,Proteomics

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Time-course RNA-Seq of ME3 cells as they undergo adipogenesis, with both control samples and samples treated with Isoproterenol

ABSTRACT: To identify and elucidate the mechanisms of adipogenic differentiation within the mouse 3t3-l1 cell line

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Laurence Dyer

PROVIDER: E-MTAB-8200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The homeobox factor Irx3 maintains adipogenic identity.

Bjune Jan-Inge JI Dyer Laurence L Røsland Gro V GV Tronstad Karl Johan KJ Njølstad Pål R PR Sagen Jørn V JV Dankel Simon N SN Mellgren Gunnar G

Metabolism: clinical and experimental 20191118

<h4>Background</h4>Inhibition of Irx3 and Irx5 has been shown to reduce body weight and white adipose tissue (WAT) mass through cell-autonomous and sympathetic-induced increases in adipocyte beiging and thermogenesis in mice and humans. However, the underlying mechanisms of the Irx control over beiging are still largely unknown, as illustrated by recent reports showing divergent effects of Irx3 on adipocyte metabolism and function. Here, we investigated the role of Irx3 in controlling beige prea ...[more]

PMID: 31751577

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