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Unknown,Transcriptomics,Genomics,Proteomics

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AXL targeting overcomes human lung cancer cell resistance to NK and CTL-mediated cytotoxicity

ABSTRACT: To investigate the effect of AXL inhibition on gene expression in carcinoma cell clones derived from NSCLC IGR-Heu cells, we profiled gene expression in cells treated with the AXL inhibitor bemcentinib (1 µmol/L) or with vehicle (dmso) for 72 hours

ORGANISM(S): Homo sapiens

SUBMITTER: Stephane Terry

PROVIDER: E-MTAB-8294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity.

Terry Stéphane S Abdou Abderemane A Engelsen Agnete S T AST Buart Stéphanie S Dessen Philippe P Corgnac Stéphanie S Collares Davi D Meurice Guillaume G Gausdal Gro G Baud Véronique V Saintigny Pierre P Lorens James B JB Thiery Jean-Paul JP Mami-Chouaib Fathia F Chouaib Salem S

Cancer immunology research 20190905 11

Immune resistance may arise from both genetic instability and tumor heterogeneity. Microenvironmental stresses such as hypoxia and various resistance mechanisms promote carcinoma cell plasticity. AXL, a member of the TAM (Tyro3, Axl, and Mer) receptor tyrosine kinase family, is widely expressed in human cancers and increasingly recognized for its role in cell plasticity and drug resistance. To investigate mechanisms of immune resistance, we studied multiple human lung cancer clones derived from ...[more]

PMID: 31488404

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