Flusilazole dose response in zebrafish embryo

ABSTRACT: The zebrafish embryotoxicity test (ZET) is considered as a useful alternative model in predictive toxicology. Currently, morphological assessment of the embryo is the main readout for this assay. However, implementation of transcriptomics may help to detect more subtle effects which may increase the sensitivity and predictability of the test. Most transcriptomics studies to date have used only a single toxicant concentration, generally selected based on the sensitivity of the classical morphological endpoint. However, effects on morphology and gene expression are dependent on compound concentration, which consequently may influence prediction of developmental toxicity. In this study, we tested a concentration-response of flusilazole in the ZET. At 24 hours post fertilization, microarray an

ORGANISM(S): Danio rerio

SUBMITTER: Tessa Pronk 

PROVIDER: E-MTAB-832 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress