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Unknown,Transcriptomics,Genomics,Proteomics

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Adipocytokines and E-cadherin in colorectal carcinomas

ABSTRACT: Expression of adipocytokines and glucocorticoid related genes are associated with down regulation of E-cadherin mRNA in colorectal carcinomas

ORGANISM(S): Homo sapiens

DISEASE(S): adenocaricinoma

SUBMITTER: Torben Luders

PROVIDER: E-MTAB-833 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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mRNA expression of adipocytokines and glucocorticoid-related genes are associated with downregulation of E-cadherin mRNA in colorectal adenocarcinomas.

Størkson Ragnhild H RH Aamodt Rolf R Vetvik Katja Kannisto KK Pietilainen Kirsi K Bukholm Geir G Jonsdottir Kristin K Vollan Hilde S HS Sonerud Tonje T Lüders Torben T Jacobsen Morten B MB Bukholm Ida R K IR

International journal of colorectal disease 20120314 8

<h4>Background</h4>There is a consistently reported relationship between the incidence of colon cancer and obesity. It is thought that adipose tissue, particularly visceral fat, which secretes systemic factors that alter immunological, metabolic and endocrine milieu and promotes insulin resistance by producing adipocytokines, is important in cancer progression. Systemic high concentrations of adipocytokines, such as tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and glucocorticoi ...[more]

PMID: 22411584

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