Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): adenocaricinoma
SUBMITTER: Torben Luders
PROVIDER: E-MTAB-833 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Størkson Ragnhild H RH Aamodt Rolf R Vetvik Katja Kannisto KK Pietilainen Kirsi K Bukholm Geir G Jonsdottir Kristin K Vollan Hilde S HS Sonerud Tonje T Lüders Torben T Jacobsen Morten B MB Bukholm Ida R K IR
International journal of colorectal disease 20120314 8
<h4>Background</h4>There is a consistently reported relationship between the incidence of colon cancer and obesity. It is thought that adipose tissue, particularly visceral fat, which secretes systemic factors that alter immunological, metabolic and endocrine milieu and promotes insulin resistance by producing adipocytokines, is important in cancer progression. Systemic high concentrations of adipocytokines, such as tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), and glucocorticoi ...[more]