RNA-seq to assess the impact of circulation on hematopoietic stem cell differentiation.
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ABSTRACT: Blood flow promotes hematopoiesis, Definitive hematopoietic stem cells can not be assessed in circulation negative Ncx-/- mice. This study looks at the impact of lack of blood flow on the earliest blood cell precursors, the pro-HSCs. E9.5 was chosen as this is the time point pro-HSCs are normally generated. Cells from the hemogenic endothelium, the endothelium and pro-HSCs were sequenced.
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Mus musculus
SUBMITTER: Chela James
PROVIDER: E-MTAB-8362 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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