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Illumina Infinium HumanMethylation EPIC beadchip profiling of 31 pediatric histologically defined anaplastic pilocytic astrocytoma

ABSTRACT: We used the Illumina Infinium HumanMethylation EPIC beadchip array to profile 31 pediatric tumors with the histological diagnosis of anaplastic pilocytic astrocyoma (PA). PA with anaplasia has been defined in the 2016 WHO classification as a tumor with PA morphology and >4 mitoses per 10 HPF, with or without necrosis with a potential worse outcome. DNA Methylation based studies performed mainly in adults have put forward this subtype as a distinct entity. After performing the same techniques on pediatric samples, our findings argue that the diagnostic histomolecular criteria established for anaplasia in adult PA are not of diagnostic or prognostic value in a pediatric setting.

ORGANISM(S): Homo sapiens

SUBMITTER: Albane Gareton

PROVIDER: E-MTAB-8390 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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