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LINT - a novel dL(3)mbt containing complex represses malignant brain tumour signature genes

ABSTRACT: Drosophila melanogaster KC cells were treated with RNAi against dL(3)mbt, dLint1 or EGFP (control) and the resulting changes in gene expression were measured.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Florian Finkernagel

PROVIDER: E-MTAB-849 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.

Meier Karin K Mathieu Eve-Lyne EL Finkernagel Florian F Reuter L Maximilian LM Scharfe Maren M Doehlemann Gunther G Jarek Michael M Brehm Alexander A

PLoS genetics 20120503 5

Mutations in the l(3)mbt tumour suppressor result in overproliferation of Drosophila larval brains. Recently, the derepression of different gene classes in l(3)mbt mutants was shown to be causal for transformation. However, the molecular mechanisms of dL(3)mbt-mediated gene repression are not understood. Here, we identify LINT, the major dL(3)mbt complex of Drosophila. LINT has three core subunits-dL(3)mbt, dCoREST, and dLint-1-and is expressed in cell lines, embryos, and larval brain. Using gen ...[more]

PMID: 22570633

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