Human dendritic cell subsets in acute skin inflammation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 4000
ORGANISM(S): Homo sapiens
SUBMITTER: Tomás Pires de Carvalho Gomes
PROVIDER: E-MTAB-8498 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Re-evaluation of human BDCA-2+ DC during acute sterile skin inflammation.
Chen Yi-Ling YL Gomes Tomas T Hardman Clare S CS Vieira Braga Felipe A FA Gutowska-Owsiak Danuta D Salimi Maryam M Gray Nicki N Duncan David A DA Reynolds Gary G Johnson David D Salio Mariolina M Cerundolo Vincenzo V Barlow Jillian L JL McKenzie Andrew N J ANJ Teichmann Sarah A SA Haniffa Muzlifah M Ogg Graham G
The Journal of experimental medicine 20200301 3
Plasmacytoid dendritic cells (pDCs) produce type I interferon (IFN-I) and are traditionally defined as being BDCA-2+CD123+. pDCs are not readily detectable in healthy human skin, but have been suggested to accumulate in wounds. Here, we describe a CD1a-bearing BDCA-2+CD123int DC subset that rapidly infiltrates human skin wounds and comprises a major DC population. Using single-cell RNA sequencing, we show that these cells are largely activated DCs acquiring features compatible with lymph node ho ...[more]
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