Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 1000
ORGANISM(S): Mus musculus
SUBMITTER: Xiaohui Zhao
PROVIDER: E-MTAB-8533 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blake Georgina E T GET Zhao Xiaohui X Yung Hong Wa HW Burton Graham J GJ Ferguson-Smith Anne C AC Hamilton Russell S RS Watson Erica D ED
Nature communications 20210617 1
The mechanism behind transgenerational epigenetic inheritance is unclear, particularly through the maternal grandparental line. We previously showed that disruption of folate metabolism in mice by the Mtrr hypomorphic mutation results in transgenerational epigenetic inheritance of congenital malformations. Either maternal grandparent can initiate this phenomenon, which persists for at least four wildtype generations. Here, we use genome-wide approaches to reveal genetic stability in the Mtrr mod ...[more]