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RNA-seq of four human glioblastoma cell lines from heterogeneous U-343 cell system

ABSTRACT: Four glioblastoma cell line U-343 MG, U-343 MGa, U-343 MGa 31L, U-343 MGa Cl2:6 were derived form the same glioblastoma U-343. The RNA-seq was performed to identify their difference and better understand the glioblastoma heterogeneity.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Min Guo

PROVIDER: E-MTAB-8620 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of functionally distinct and interacting cancer cell subpopulations from glioblastoma with intratumoral genetic heterogeneity.

Guo Min M van Vliet Marjolein M Zhao Jian J de Ståhl Teresita Díaz TD Lindström Mikael S MS Cheng Huaitao H Heller Susanne S Nistér Monica M Hägerstrand Daniel D

Neuro-oncology advances 20200101 1

<h4>Background</h4>Glioblastomas display a high level of intratumoral heterogeneity with regard to both genetic and histological features. Within single tumors, subclones have been shown to communicate with each other to affect overall tumor growth. The aim of this study was to broaden the understanding of interclonal communication in glioblastoma.<h4>Methods</h4>We have used the U-343 model, consisting of U-343 MG, U-343 MGa, U-343 MGa 31L, and U-343 MGa Cl2:6, a set of distinct glioblastoma ce ...[more]

PMID: 32642713

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