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Development and Independent Validation of a Prognostic Assay for Stage II Colon Cancer using Formalin Fixed Paraffin Embedded Tissue_Training Set


ABSTRACT: Current prognostic factors are poor at identifying patients at risk of disease recurrence following surgery for stage II colon cancer. Here we describe a DNA microarray based prognostic assay using clinically relevant formalin fixed paraffin embedded (FFPE) samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Peter Hey 

PROVIDER: E-MTAB-863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Development and independent validation of a prognostic assay for stage II colon cancer using formalin-fixed paraffin-embedded tissue.

Kennedy Richard D RD   Bylesjo Max M   Kerr Peter P   Davison Timothy T   Black Julie M JM   Kay Elaine W EW   Holt Robert J RJ   Proutski Vitali V   Ahdesmaki Miika M   Farztdinov Vadim V   Goffard Nicolas N   Hey Peter P   McDyer Fionnuala F   Mulligan Karl K   Mussen Julie J   O'Brien Eamonn E   Oliver Gavin G   Walker Steven M SM   Mulligan Jude M JM   Wilson Claire C   Winter Andreas A   O'Donoghue Diarmuid D   Mulcahy Hugh H   O'Sullivan Jacintha J   Sheahan Kieran K   Hyland John J   Dhir Rajiv R   Bathe Oliver F OF   Winqvist Ola O   Manne Upender U   Shanmugam Chandrakumar C   Ramaswamy Sridhar S   Leon Eduardo J EJ   Smith William I WI   McDermott Ultan U   Wilson Richard H RH   Longley Daniel D   Marshall John J   Cummins Robert R   Sargent Daniel J DJ   Johnston Patrick G PG   Harkin D Paul DP  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111107 35


<h4>Purpose</h4>Current prognostic factors are poor at identifying patients at risk of disease recurrence after surgery for stage II colon cancer. Here we describe a DNA microarray-based prognostic assay using clinically relevant formalin-fixed paraffin-embedded (FFPE) samples.<h4>Patients and methods</h4>A gene signature was developed from a balanced set of 73 patients with recurrent disease (high risk) and 142 patients with no recurrence (low risk) within 5 years of surgery.<h4>Results</h4>The  ...[more]

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