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Transcriptional profiling of patient-derived xenograft models of myxoid liposarcoma either responsive or resistant to trabectedin treatment.

ABSTRACT: Transcriptional profiling of patient-derived xenograft models of myxoid liposarcoma with either FUS-CHOP type I, named as ML017, or FUS-CHOP type III, named as ML006. Both ML017 and ML006 are responsive to trabectedin treatment, while model ML017/ET has aquired resistance to the drug. Samples are either under untreated conditions, or treated either with trabectedin or pioglitazone or both.

ORGANISM(S): Homo sapiens

SUBMITTER: Laura Mannarino

PROVIDER: E-MTAB-8632 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Establishment and characterisation of a new patient-derived model of myxoid liposarcoma with acquired resistance to trabectedin.

Bello Ezia E Brich Silvia S Craparotta Ilaria I Mannarino Laura L Ballabio Sara S Gatta Raffaella R Marchini Sergio S Carrassa Laura L Matteo Cristina C Sanfilippo Roberta R Gronchi Alessandro A Casali Paolo Giovanni PG Pilotti Silvana S D'Incalci Maurizio M Frapolli Roberta R

British journal of cancer 20190814 6

<h4>Background</h4>Myxoid liposarcoma is a histological subtype of liposarcoma particularly sensitive to trabectedin. In clinical use this drug does not cause cumulative toxicity, allowing prolonged treatment, generally until disease progression. No other effective therapies are available for trabectedin-resistant patients.<h4>Methods</h4>Through repeated in vivo treatment in athymic nude mice, we have obtained a patient-derived xenograft with acquired resistance to trabectedin.<h4>Results</h4>A ...[more]

PMID: 31409911

Publication: 1/2

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