Comparison of transcription profile of Adenosine receptor (AdoR) null mutant and adenosine transporter (ENT2) partial mutant in Drosophila melanogaster 3rd instar larvae
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ABSTRACT: Dysregulation of adenosine (Ado) homeostasis has been observed in both rodent models and human patients of Huntington’s disease (HD). However, the underlying mechanisms of Ado signaling in HD pathogenesis is still unclear. In this study we examined influence of Ado signaling on Drosophila HD model. We further compared the transcription profiles of AdoR and ENT2 mutants by microarray analysis to identify a downstream target of AdoR signaling, which mediates the AdoR effects on HD pathology. Our findings have important implications for the crosstalk between Ado signaling and pathogenic effects of HD as well as other human diseases associated with polyglutamine aggregation.
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Yu-Hsien Lin
PROVIDER: E-MTAB-8699 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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