Unknown,Transcriptomics,Genomics,Proteomics

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RNA-seq of male and female mouse brown adipose tissue (BAT) transcriptome


ABSTRACT: The interscapular brown adipose tissue (BAT) depots of adult male and female C57BL/6J mice, housed at 22 °C, were analyzed to identify sex differences in the BAT transcriptome at basal housing conditions.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Mus musculus

SUBMITTER: Jenny Visser 

PROVIDER: E-MTAB-8717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Sex difference in the mouse BAT transcriptome reveals a role of progesterone.

Kaikaew Kasiphak K   Grefhorst Aldo A   Steenbergen Jacobie J   Swagemakers Sigrid M A SMA   McLuskey Anke A   Visser Jenny A JA  

Journal of molecular endocrinology 20210201 2


Brown adipose tissue (BAT) is a metabolically active organ that exhibits sex-differential features, that is, being generally more abundant and active in females than in males. Although sex steroids, particularly estrogens, have been shown to regulate BAT thermogenic function, the underlying molecular mechanisms contributing to sexual dimorphism in basal BAT activity have not been elucidated. Therefore, we assessed the transcriptome of interscapular BAT of male and female C57BL/6J mice by RNA seq  ...[more]

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