Ontology highlight
ABSTRACT:
INSTRUMENT(S): NextSeq 500
ORGANISM(S): Mus musculus
SUBMITTER: Jana Vukovic
PROVIDER: E-MTAB-8765 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Willis Emily F EF MacDonald Kelli P A KPA Nguyen Quan H QH Garrido Adahir Labrador AL Gillespie Ellen R ER Harley Samuel B R SBR Bartlett Perry F PF Schroder Wayne A WA Yates Abi G AG Anthony Daniel C DC Rose-John Stefan S Ruitenberg Marc J MJ Vukovic Jana J
Cell 20200301 5
Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood. Here, we show that removal of microglia from the mouse brain has little effect on the outcome of TBI, but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a neuroprotective microglial phenotype that profoundly aids recovery. The beneficia ...[more]