Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Regulatory and effector T cells in Lymphocytic choriomeningitis virus WE infection


ABSTRACT: In this study, we determined the signature of CD4+Foxp3- effector T cells and CD4+Foxp3+ Treg cells in naive animals and following LCMV WE infection. In addition, transcriptional signatures were determined in CXCR3+ CD4+Foxp3+ Treg cells arising in Th1 settings following LCMV infection.

INSTRUMENT(S): Illumina HiSeq 3000

ORGANISM(S): Mus musculus

SUBMITTER: Nicole Joller 

PROVIDER: E-MTAB-8861 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications


CD4<sup>+</sup>Foxp3<sup>+</sup> Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXCR3 directs Treg cells to the site of inflammation. However, the suppressive mediators enabling effective control of Th1 responses at this site are unknown. In this study, we dete  ...[more]

Similar Datasets

2018-06-30 | E-MTAB-6156 | biostudies-arrayexpress
2020-01-31 | E-MTAB-7961 | biostudies-arrayexpress
2013-06-06 | E-GEOD-30847 | biostudies-arrayexpress
2009-09-15 | E-GEOD-16210 | biostudies-arrayexpress
2015-04-30 | E-GEOD-61834 | biostudies-arrayexpress
2012-11-05 | E-GEOD-25252 | biostudies-arrayexpress
2016-06-28 | E-GEOD-83743 | biostudies-arrayexpress
2013-07-03 | E-GEOD-39724 | biostudies-arrayexpress
2017-04-10 | PXD004436 | Pride
2024-06-08 | PXD019050 | Pride