Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 3000
ORGANISM(S): Mus musculus
SUBMITTER: Nicole Joller
PROVIDER: E-MTAB-8861 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Littringer Katharina K Moresi Claudia C Rakebrandt Nikolas N Zhou Xiaobei X Schorer Michelle M Dolowschiak Tamas T Kirchner Florian F Rost Felix F Keller Christian W CW McHugh Donal D LeibundGut-Landmann Salomé S Robinson Mark D MD Joller Nicole N
Frontiers in immunology 20180613
CD4<sup>+</sup>Foxp3<sup>+</sup> Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXCR3 directs Treg cells to the site of inflammation. However, the suppressive mediators enabling effective control of Th1 responses at this site are unknown. In this study, we dete ...[more]