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Unknown,Transcriptomics,Genomics,Proteomics

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MRNA microarray data from patients with non-active gastritis, chronic active gastritis and precursor lesions of gastric cancer

ABSTRACT: Helicobacter pylori infection can induce gastric pathologies ranging from chronic gastritis to peptic ulcers and gastric cancer. Individuals´ response to H. pylori infection is complex and it depends on a combination of environmental factors, genetic background, host response and strain virulence. The pathway towards gastric cancer is a sequence of events known as the Correa's model of gastric carcinogenesis, a stepwise inflammatory process from normal mucosa to chronic active gastritis, atrophy, metaplasia and finally gastric adenocarcinoma. This study explores gastric clinical specimens representing different steps of the Correa pathway with the aim of identifying the expression profile of coding- and non-coding RNAs (microRNAs and small RNAs) which may have a role in the Correa's model of gastric carcinogenesis and potentially develop novel clinical biomarkers. We screened for differentially expressed genes in gastric biopsies (antrum/corpus) by employing RNAseq (for microRNAs and non-coding RNAs) and microarrays (for coding RNAs).

ORGANISM(S): Homo sapiens

SUBMITTER: Sergio Lario

PROVIDER: E-MTAB-8889 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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