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High-throughput sequencing of IgH gene in minor salivary glands from Sjögren’s syndrome patients reveals dynamic ectopic lymphoid structures with recirculating B cells

ABSTRACT: This study is the first of this kind performed on minor salivary glands (mSG) of patients with Sjögren’s Syndrome. It shows that B cells clones are able to circulate across different glands and once re-seeded in a different mSG to continue the process of somatic hypermutation and switching of the immunoglobulin genes. Understanding B cells behavior in organs affected by autoantibodies, may help in designing personalized therapies, using monoclonal antibodies that target B cells (e.g. Rituximab) only on those patients that have a higher chance to respond.

INSTRUMENT(S): 454 GS FLX Titanium

ORGANISM(S): Homo sapiens

SUBMITTER: Elisa Corsiero

PROVIDER: E-MTAB-9065 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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