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TEX15 is an essential executor of MIWI2-directed transposon DNA methylation and silencing.

ABSTRACT: The PIWI protein MIWI2 and its associated PIWI-interacting RNAs (piRNAs) instruct DNA methylation of young active transposable elements (TEs) in the male germline. Here we show that MIWI2 associates with TEX15 in foetal gonocytes. TEX15 is predominantly a nuclear protein that is not required for piRNA biogenesis but is essential for piRNA-directed TE de novo methylation and silencing. In summary, TEX15 is an essential executor of mammalian piRNA-directed DNA methylation.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Donal O'Carroll

PROVIDER: E-MTAB-9090 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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