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Gene expression profile of subcutaneous panniculitis-like T-cell Lymphoma

ABSTRACT: Gene expression profiling from skin tissue samples. Pre-treatment = sample taken before any treatment at the time of SPTL diagnosis, post-treatment 1 = sample taken during treatment after 3 to 6 months of diagnosis and post-treatment 2 = sample taken during treatment after 6 to 12 months of diagnosis.

ORGANISM(S): Homo sapiens

SUBMITTER: Pilvi Maliniemi

PROVIDER: E-MTAB-910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes.

Maliniemi Pilvi P Hahtola Sonja S Ovaska Kristian K Jeskanen Leila L Väkevä Liisa L Jäntti Kirsi K Stadler Rudolf R Michonneau David D Fraitag Sylvie S Hautaniemi Sampsa S Ranki Annamari A

Orphanet journal of rare diseases 20141112

<h4>Background</h4>Subcutaneous panniculitis-like T cell lymphomas represent a rare and difficult to diagnose entity of cutaneous T cell lymphomas. SPTL affects predominantly young adults and presents with multifocal subcutaneous nodules and frequently associated autoimmune features. The pathogenesis of SPTL is not completely understood.<h4>Methods</h4>The aim of this study was to unravel molecular pathways critical to the SPTL pathogenesis. Therefore, we analyzed 23 skin samples from 20 newly d ...[more]

PMID: 25928531

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