Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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MOF, H4 and H4K16ac ChIP-seq experiments in D.melanogaster


ABSTRACT: We generated MOF, H4 and H4K16ac ChIP-seq experiments in D.melanogaster male and female wt. All experiments were performed with 3rd instard salivary glands biological material. Raw and processed data are provided here.

INSTRUMENT(S): Illumina Genome Analyzer II

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Florence Cavalli 

PROVIDER: E-MTAB-911 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The MOF chromobarrel domain controls genome-wide H4K16 acetylation and spreading of the MSL complex.

Conrad Thomas T   Cavalli Florence M G FM   Holz Herbert H   Hallacli Erinc E   Kind Jop J   Ilik Ibrahim I   Vaquerizas Juan M JM   Luscombe Nicholas M NM   Akhtar Asifa A  

Developmental cell 20120301 3


The histone H4 lysine 16 (H4K16)-specific acetyltransferase MOF is part of two distinct complexes involved in X chromosome dosage compensation and autosomal transcription regulation. Here we show that the MOF chromobarrel domain is essential for H4K16 acetylation throughout the Drosophila genome and is required for spreading of the male-specific lethal (MSL) complex on the X chromosome. The MOF chromobarrel domain directly interacts with nucleic acids and potentiates MOF's enzymatic activity aft  ...[more]

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