Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina Genome Analyzer II
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Florence Cavalli
PROVIDER: E-MTAB-911 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Conrad Thomas T Cavalli Florence M G FM Holz Herbert H Hallacli Erinc E Kind Jop J Ilik Ibrahim I Vaquerizas Juan M JM Luscombe Nicholas M NM Akhtar Asifa A
Developmental cell 20120301 3
The histone H4 lysine 16 (H4K16)-specific acetyltransferase MOF is part of two distinct complexes involved in X chromosome dosage compensation and autosomal transcription regulation. Here we show that the MOF chromobarrel domain is essential for H4K16 acetylation throughout the Drosophila genome and is required for spreading of the male-specific lethal (MSL) complex on the X chromosome. The MOF chromobarrel domain directly interacts with nucleic acids and potentiates MOF's enzymatic activity aft ...[more]