Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents

ABSTRACT: We aimed to identify blood gene expression patterns associated to psychopathological trajectories retrieved from a large community, focusing on the emergence and remission of general psychiatric symptoms. Hundred and three individuals from the Brazilian High-Risk Cohort Study (BHRCS) for mental disorders were classified in four groups according to Child Behavior Checklist (CBCL) total score at the baseline (w0) and after 3 years (w1): low–high (L–H) (N = 27), high–low (H–L) (N = 12), high–high (H–H) (N = 34) and low–low (L–L) groups (N = 30). Blood gene expression profile was measured using Illumina HT-12 Beadchips, and paired analyses comparing w0 and w1 were performed for each group.

ORGANISM(S): Homo sapiens

SUBMITTER: Marcos Santoro

PROVIDER: E-MTAB-9200 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths.

Spindola Leticia M LM Santoro Marcos L ML Pan Pedro M PM Ota Vanessa K VK Xavier Gabriela G Carvalho Carolina M CM Talarico Fernanda F Sleiman Patrick P March Michael M Pellegrino Renata R Brietzke Elisa E Grassi-Oliveira Rodrigo R Mari Jair J JJ Gadelha Ary A Miguel Euripedes C EC Rohde Luis A LA Bressan Rodrigo A RA Mazzotti Diego R DR Sato João R JR Salum Giovanni A GA Hakonarson Hakon H Belangero Sintia I SI

Clinical epigenetics 20191021 1

<h4>Background</h4>Psychiatric symptomatology during late childhood and early adolescence tends to persist later in life. In the present longitudinal study, we aimed to identify changes in genome-wide DNA methylation patterns that were associated with the emergence of psychopathology in youths from the Brazilian High-Risk Cohort (HRC) for psychiatric disorders. Moreover, for the differentially methylated genes, we verified whether differences in DNA methylation corresponded to differences in mRN ...[more]

PMID: 31639064

Publication: 1/2

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Dataset Information

Gene expression changes associated with trajectories of psychopathology in a longitudinal cohort of children and adolescents

Publications

Detecting multiple differentially methylated CpG sites and regions related to dimensional psychopathology in youths.

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