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Integrative genomic analysis of blood pressure and related phenotypes in rats

ABSTRACT: Despite remarkable progress made in human genome-wide association studies, there remains a substantial gap between statistical evidence for genetic association and functional comprehension of the underlying mechanisms. To bridge the gap, we perform integrative genomic analysis of blood pressure and related phenotypes in the spontaneously hypertensive rat, an animal model of essential hypertension, searching causal genes and causal pathways. We identify 28 potential target genes, including rat homologs of human transcriptome-wide association study loci, for the tested traits and provide experimental evidence supporting the presence of key disease pathways and core disease-related gene loci in the genetic architecture of hypertension.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Norihiro Kato

PROVIDER: E-MTAB-9244 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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