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Methylation array profiling of DIPG tumours, patient-derived cell culture, and patient-derived xenografts from the BIOMEDE phase II prospective trial

ABSTRACT: BIOMEDE (NCT02233049) was a phase II, biopsy-driven clinical trial in DIPG patients with randomisation of stratification between dasatinib, erlotinib and everolimus. Methylation array profiling was carried out alongside drug screening in newly-established patient-derived models of DIPG in vitro and in vivo. Alongside exome, RNAseq, phospho-proteomics, these data highlight the MAPK pathway as a therapeutic target in DIPG, and show the importance of parallel resistance modelling and rational combinatorial treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Alan Mackay

PROVIDER: E-MTAB-9282 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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