Human keratinocyte sensitizing potential
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jochem van der Veen
PROVIDER: E-MTAB-943 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Applicability of a keratinocyte gene signature to predict skin sensitizing potential.
van der Veen Jochem W JW Pronk Tessa E TE van Loveren Henk H Ezendam Janine J
Toxicology in vitro : an international journal published in association with BIBRA 20120828 1
There is a need to replace animal tests for the identification of skin sensitizers and currently many alternative assays are being developed that have very promising results. In this study a gene signature capable of very accurate identification of sensitizers was established in the HaCaT human keratinocyte cell line. This signature was evaluated in a separate study using six chemicals that are either local lymph node (LLNA) false-positive or false-negative chemicals in addition to nine sensitiz ...[more]
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