Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Comparison of receptor tyrosine kinase (RTK) family gene expression between normoxic cells and hypoxia-induced gefitinib resistant clones


ABSTRACT: In this study, we explored the mechanisms of hypoxia-induced EGFR TKI resistance in non-small cell lung cancer (NSCLC) harbored activating EGFR mutation. The NSCLC cell lines were exposed to normorxia or 1% oxygen for 4 weeks, and then we tested EGFR TKI sensitivity in normoxic and hypoxic NSCLC cell lines. In this microarray experiment, we used normoxic HCC827 and hypoxia-induced gefitinib resistant clones, C2-3 and C2-10. Those clones were selected with gefitinib treatment after the HCC827 were exposed to 1% oxygen for 4 weeks, and the HCC827 C2-3 and C2-10 clones were selected at random for this study.

ORGANISM(S): Homo sapiens

SUBMITTER: Yuhong Lu 

PROVIDER: E-MTAB-9452 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2016-08-23 | E-GEOD-74575 | biostudies-arrayexpress
2016-07-01 | E-GEOD-75307 | biostudies-arrayexpress
2016-03-29 | E-GEOD-79688 | biostudies-arrayexpress
2011-01-27 | E-GEOD-23206 | biostudies-arrayexpress
2016-07-01 | E-GEOD-75308 | biostudies-arrayexpress
2014-01-01 | E-GEOD-34228 | biostudies-arrayexpress
2012-05-29 | E-GEOD-38310 | biostudies-arrayexpress
2019-02-07 | GSE122005 | GEO
2014-10-07 | E-GEOD-62118 | biostudies-arrayexpress
2016-07-01 | GSE75308 | GEO