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Reduction of PRC2 activity supports survival of TNBC cancer cells to cytotoxic treatments.

ABSTRACT: Basal-like breast cancer generally shows a good response to conventional cytotoxic but rapidly develops a resistant phenotype. To better understand the epigenetic changes underlying the acquisition of resistant properties, we treated the murine basal-like mammary carcinoma cell line G-2 for 48 hours with sublethal combination chemotherapy (Cyclophosphamide, Adriamycin, 5-Fluorouracil) and subsequently subjected them to RNA- and ChIP-sequencing.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Mus musculus

SUBMITTER: Florian Wegwitz

PROVIDER: E-MTAB-9584 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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