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Immune profiles identification by vaccinomics after MVA immunization in randomized clinical study

ABSTRACT: Whole blood transcriptomics analysis of healthy individuals, immunized with the MVA-B vaccine via transcutaneous or intramuscular route. We define an early gene expression profile, detected at day 1 and day 7 after immunization, that is associated with the development of either MVA specific humoral or CD8 T cell responses. We used System Biology approach to analyse vaccine efficacy in order to find innate predictive biomarkers of the quality of adaptive responses for potential clinical use in the future. Moreover, from a methodological point of view this study increases knowledges on how vaccine route(s) can affect resulting immune responses and into mechanisms involved in the induction of humoral and cellular immunity to vaccine.

ORGANISM(S): Homo sapiens

SUBMITTER: Elena Goncalves

PROVIDER: E-MTAB-9642 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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