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ChIP-seq of H3-K4me3 from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

ABSTRACT: The intent of the experiment was to compare H3-K4me3 peaks on the chromatin of WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Carl MANN

PROVIDER: E-MTAB-9718 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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RNA-seq of small RNAs in WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence

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RNA-seq of rRNA-depleted total RNAs in WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

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Transcriptome analysis by Illumina microarrays of the effect of overexpressing H2A.J mutants, or WT H2A.J or canonical H2A, on the transcriptome of WI-38hTERT fibroblasts

Project description:The intent of the experiment was to test the effect of overexpressing H2A.J-V11A, H2AJ-S123E, H2A.J-S123A, and H2A.J-CterH2A mutants, as well as WT-H2A.J and canonical H2A-type1, on the transcriptome of WI-38hTERT fibroblasts. pTRIPz based lentiviral constructs placing these coding sequences under tetON control were used to produce stable WI38hTERT cell lines for each construct. Expression of the constructs in proliferating cells was induced with 100 ng/ml doxycycline for è days. Transcriptomes were also compared with control proliferating WI-38hTERT and WI-38hTERT cells induced into senescence by incubation with 20 µM etoposide for 2 weeks followed by 1 week without etoposide.

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ChIP-seq of H3-K4me3 from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

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ChIP-seq of RNA polymerase II from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

Project description:ChIP-seq of RNA polymerase II from WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

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RNA-seq of rRNA-depleted total RNAs in WI-38hTERT/sh3-H2AFJ and WI-38hTERT/sh-NT fibroblasts in proliferation and etoposide-induced senescence.

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Transcriptomic datat of senescence WI-38 cell

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