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Transcription profiling by array of mouse wild type or CD27-/- OT-I T cells are stimulated with artficial antigen presenting cell lines expressing CD70 and/or CD80

ABSTRACT: WT or CD27-/- OT-I T cells are stimulated in vitro with artficial antigen presenting cell (aAPC) lines expressing CD70 and/or CD80 for 2, 4, 8 or 14 hours.

ORGANISM(S): Mus musculus

SUBMITTER: Victor Peperzak

PROVIDER: E-NCMF-38 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD8+ T cells produce the chemokine CXCL10 in response to CD27/CD70 costimulation to promote generation of the CD8+ effector T cell pool.

Peperzak Victor V Veraar Elise A M EA Xiao Yanling Y Babala Nikolina N Thiadens Klaske K Brugmans Marieke M Borst Jannie J

Journal of immunology (Baltimore, Md. : 1950) 20130812 6

Various cell types can produce the chemokine CXCL10 in response to IFN-γ stimulation. CXCL10 is generally viewed as a proinflammatory chemokine that promotes recruitment of CD8÷ and Th1-type CD4÷ effector T cells to infected or inflamed nonlymphoid tissues. We show that CXCL10 plays a role during CD8÷ T cell priming in the mouse. Genome-wide expression profiling revealed the Cxcl10 gene as a target of CD27/CD70 costimulation in newly activated CD8÷ T cells. CD27/CD70 costimulation is known to pr ...[more]

PMID: 23940275

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