Transcription profiling of yeast - poly(A) mRNA decay data set
Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Tina Boussard
PROVIDER: E-SMDB-1263 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Precision and functional specificity in mRNA decay.
Wang Yulei Y Liu Chih Long CL Storey John D JD Tibshirani Robert J RJ Herschlag Daniel D Brown Patrick O PO
Proceedings of the National Academy of Sciences of the United States of America 20020423 9
Posttranscriptional processing of mRNA is an integral component of the gene expression program. By using DNA microarrays, we precisely measured the decay of each yeast mRNA, after thermal inactivation of a temperature-sensitive RNA polymerase II. The half-lives varied widely, ranging from approximately 3 min to more than 90 min. We found no simple correlation between mRNA half-lives and ORF size, codon bias, ribosome density, or abundance. However, the decay rates of mRNAs encoding groups of pro ...[more]
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