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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of response of Bacillus subtilis to peroxide stress

ABSTRACT:

ORGANISM(S): Bacillus subtilis

SUBMITTER: Tina Boussard

PROVIDER: E-SMDB-1775 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The global transcriptional response of Bacillus subtilis to peroxide stress is coordinated by three transcription factors.

Helmann John D JD Wu Ming Fang Winston MF Gaballa Ahmed A Kobel Phil A PA Morshedi Maud M MM Fawcett Paul P Paddon Chris C

Journal of bacteriology 20030101 1

Bacillus subtilis exhibits a complex adaptive response to low levels of peroxides. We used global transcriptional profiling to monitor the magnitude and kinetics of changes in the mRNA population after exposure to either hydrogen peroxide (H(2)O(2)) or tert-butyl peroxide (t-buOOH). The peroxide stimulons could be largely accounted for by three regulons controlled by the PerR, sigma(B), and OhrR transcription factors. Three members of the PerR regulon (katA, mrgA, and zosA) were strongly induced ...[more]

PMID: 12486061

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