Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of yeast cdc15 block-release (Spellman et al.)

ABSTRACT: Reproduced from P. T. Spellman, G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein and B. Futcher, "Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization," Molecular Biology of the Cell 9 (12), pp. 3273--3297 (December 1998).

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-1886 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Singular value decomposition for genome-wide expression data processing and modeling.

Alter O O   Brown P O PO   Botstein D D  

Proceedings of the National Academy of Sciences of the United States of America 20000801 18

We describe the use of singular value decomposition in transforming genome-wide expression data from genes x arrays space to reduced diagonalized "eigengenes" x "eigenarrays" space, where the eigengenes (or eigenarrays) are unique orthonormal superpositions of the genes (or arrays). Normalizing the data by filtering out the eigengenes (and eigenarrays) that are inferred to represent noise or experimental artifacts enables meaningful comparison of the expression of different genes across differen  ...[more]

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