Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of cell cycle in HeLa S3 cells, double thymidine block, rxperiment 2

ABSTRACT: HeLa S3 cells were synchronized in early S phase with a double thymidine block as described in Whitfield et al(2002)Mol.Biol.Cell. This experiment set contains the complete set of 24K arrays for the second double thymidine block synchronization (Thy-Thy2).

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-902 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of genes periodically expressed in the human cell cycle and their expression in tumors.

Whitfield Michael L ML   Sherlock Gavin G   Saldanha Alok J AJ   Murray John I JI   Ball Catherine A CA   Alexander Karen E KE   Matese John C JC   Perou Charles M CM   Hurt Myra M MM   Brown Patrick O PO   Botstein David D  

Molecular biology of the cell 20020601 6

The genome-wide program of gene expression during the cell division cycle in a human cancer cell line (HeLa) was characterized using cDNA microarrays. Transcripts of >850 genes showed periodic variation during the cell cycle. Hierarchical clustering of the expression patterns revealed coexpressed groups of previously well-characterized genes involved in essential cell cycle processes such as DNA replication, chromosome segregation, and cell adhesion along with genes of uncharacterized function.  ...[more]

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