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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of yeast population cultured for many generations under conditions to which it is not optimally adapted

ABSTRACT: This experiment set contains the arrays referenced in Ferea, TL, et al. titled "Systematic changes in gene expression patterns following adaptive evolution in yeast"(Proc Natl Acad Sci USA 1999 96(17):9721-6). A Saccharomyces cerevisiae population was cultured for many generations under conditions to which it is not optimally adapted. These experiments were designed to investigate adaptive evolution under natural selection.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Tina Boussard

PROVIDER: E-SMDB-98 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systematic changes in gene expression patterns following adaptive evolution in yeast.

Ferea T L TL Botstein D D Brown P O PO Rosenzweig R F RF

Proceedings of the National Academy of Sciences of the United States of America 19990801 17

Culturing a population of Saccharomyces cerevisiae for many generations under conditions to which it is not optimally adapted selects for fitter genetic variants. This simple experimental design provides a tractable model of adaptive evolution under natural selection. Beginning with a clonal, founding population, independently evolved strains were obtained from three independent cultures after continuous aerobic growth in glucose-limited chemostats for more than 250 generations. DNA microarrays ...[more]

PMID: 10449761

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