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MCAM GIST

ABSTRACT: To examine methylation profile of the CpG promoters in clinical sample of GISTs.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER:

PROVIDER: E-TABM-1022 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumour.

Okamoto Yasuyuki Y Sawaki Akira A Ito Seiji S Nishida Toshirou T Takahashi Tsuyoshi T Toyota Minoru M Suzuki Hiromu H Shinomura Yasuhisa Y Takeuchi Ichiro I Shinjo Keiko K An Byonggu B Ito Hidemi H Yamao Kenji K Fujii Makiko M Murakami Hideki H Osada Hirotaka H Kataoka Hiromi H Joh Takashi T Sekido Yoshitaka Y Kondo Yutaka Y

Gut 20110627 3

<h4>Background and aims</h4>The majority of gastrointestinal stromal tumors (GISTs) have KIT mutations; however, epigenetic abnormalities that could conceivably potentiate the aggressiveness of GISTs are largely unidentified. Our aim was to establish epigenetic profiles associated with the malignant transformation of GISTs.<h4>Methods</h4>Methylation of four tumor suppressor genes, RASSF1A, p16, CDH1, and MGMT was analyzed in GISTs. Additionally, genome-wide DNA methylation profiles were compare ...[more]

PMID: 21708825

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