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Methylation profiling by array of mouse liver, brain and heart tissues

ABSTRACT: Genome-wide DNA methylation profiling of the mouse liver, brain and heart tissues analyzed by D-REAM

ORGANISM(S): Mus musculus

SUBMITTER: Shinya Sato

PROVIDER: E-TABM-1026 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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DNA methylation status of nuclear-encoded mitochondrial genes underlies the tissue-dependent mitochondrial functions.

Takasugi Masaki M Yagi Shintaro S Hirabayashi Keiji K Shiota Kunio K

BMC genomics 20100819

<h4>Background</h4>Mitochondria are semi-autonomous, semi-self-replicating organelles harboring their own DNA (mitochondrial DNA, mtDNA), and their dysregulation is involved in the development of various diseases. While mtDNA does not generally undergo epigenetic modifications, almost all mitochondrial proteins are encoded by nuclear DNA. However, the epigenetic regulation of nuclear-encoded mitochondrial genes (nuclear mt genes) has not been comprehensively analyzed.<h4>Results</h4>We analyzed ...[more]

PMID: 20723256

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