Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human myeloma cell lines


ABSTRACT: 30 human myeloma cell lines

ORGANISM(S): Homo sapiens

SUBMITTER: Jerome Moreaux 

PROVIDER: E-TABM-1088 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Myeloma cells are sensitive to TRAIL through the two death receptors DR4 and DR5. Because p53 directly modulates expression of death receptors, we investigated here whether p53 can modulate myeloma sensitivity to TRAIL. We found that p53 affects the sensitivity of myeloma cells to the DR5 agonistic human antibody lexatumumab but not the DR4 antibody mapatumumab. TP53 wild-type myeloma cells overexpressed DR5 in correlation with sensitivity to lexatumumab. Both nongenotoxic (nutlin-3a) and genoto  ...[more]

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