Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Jerome Moreaux
PROVIDER: E-TABM-1088 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Surget Sylvanie S Chiron David D Gomez-Bougie Patricia P Descamps Géraldine G Ménoret Emmanuelle E Bataille Régis R Moreau Philippe P Le Gouill Steven S Amiot Martine M Pellat-Deceunynck Catherine C
Cancer research 20120627 17
Myeloma cells are sensitive to TRAIL through the two death receptors DR4 and DR5. Because p53 directly modulates expression of death receptors, we investigated here whether p53 can modulate myeloma sensitivity to TRAIL. We found that p53 affects the sensitivity of myeloma cells to the DR5 agonistic human antibody lexatumumab but not the DR4 antibody mapatumumab. TP53 wild-type myeloma cells overexpressed DR5 in correlation with sensitivity to lexatumumab. Both nongenotoxic (nutlin-3a) and genoto ...[more]