Unknown,Transcriptomics,Genomics,Proteomics

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Blood and lymph node response to respiratory syncytial virus infection in mice


ABSTRACT: Transcriptional responses in lymph nodes and blood of mice infected with RSV

ORGANISM(S): Mus musculus

SUBMITTER: Jeroen Pennings 

PROVIDER: E-TABM-1094 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Respiratory Syncytial Virus is a frequent cause of severe bronchiolitis in children. To improve our understanding of systemic host responses to RSV, we compared BALB/c mouse gene expression responses at day 1, 2, and 5 during primary RSV infection in lung, bronchial lymph nodes, and blood. We identified a set of 53 interferon-associated and innate immunity genes that give correlated responses in all three murine tissues. Additionally, we identified blood gene signatures that are indicative of ac  ...[more]

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