Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

IGR_GLIOMA_STUDY_SP

ABSTRACT: Glioma study (gene expression and CGH): Brain tumours are the most common solid tumors in children and have the highest mortality rate of all solid pediatric tumours. Despite advances in multimodality therapy, children with high-grade gliomas invariably have an Overall Survival (OS) around 20% at 5 years. There is growing evidence that the biological knowledge and the histo-prognostic classifications used for the management of adult HGG may not fully apply to children. Interobserver variability and specificity of pediatric tumors with respect to the World Health Organization (WHO) classification have lead to a high rate of misclassification in multi-institutional studies. From 90 biopsies of children with HGG (High Grade Glioma), comprising 37 DIPG (Diffuse Infiltrating Pontine Glioma), 73 extracted RNA have been hybrized on Agilent 4x44K GE arrays and 71 extracted DNA have been hybrized on Agilent 44K and 4x44K CGH arrays. The dataset contains raw data files from Feature Extraction. Genomic data were jointly analysed with clinical and histological data comprising: date_of_diagnosis, date_of_last_news, WHO_grade, deceased_at_median_survival_time, deceased_at_2years, localization of the tumour in brain, gadolinium_T1_inf_T2. A specific analysis was performed on DIPG.

ORGANISM(S): Homo sapiens

DISEASE(S): central nervous system cancer

SUBMITTER:

PROVIDER: E-TABM-1107 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.

Puget Stephanie S Philippe Cathy C Bax Dorine A DA Job Bastien B Varlet Pascale P Junier Marie-Pierre MP Andreiuolo Felipe F Carvalho Dina D Reis Ricardo R Guerrini-Rousseau Lea L Roujeau Thomas T Dessen Philippe P Richon Catherine C Lazar Vladimir V Le Teuff Gwenael G Sainte-Rose Christian C Geoerger Birgit B Vassal Gilles G Jones Chris C Grill Jacques J

PloS one 20120228 2

Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain tumor and its prognosis is universaly fatal. No significant improvement has been made in last thirty years over the standard treatment with radiotherapy. To address the paucity of understanding of DIPGs, we have carried out integrated molecular profiling of a large series of samples obtained with stereotactic biopsy at diagnosis. While chromosomal imbalances did not distinguish DIPG and supratentorial t ...[more]

PMID: 22389665

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Dataset Information

IGR_GLIOMA_STUDY_SP

Publications

Mesenchymal transition and PDGFRA amplification/mutation are key distinct oncogenic events in pediatric diffuse intrinsic pontine gliomas.

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