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Normal mesothelial cells and malignant mesothelioma cells treated with TGF-B

ABSTRACT:

ORGANISM(S): Homo sapiens

SUBMITTER: Makiko Fujii

PROVIDER: E-TABM-1144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth.

Fujii Makiko M Toyoda Takeshi T Nakanishi Hayao H Yatabe Yasushi Y Sato Ayuko A Matsudaira Yasue Y Ito Hidemi H Murakami Hideki H Kondo Yutaka Y Kondo Eisaku E Hida Toyoaki T Tsujimura Tohru T Osada Hirotaka H Sekido Yoshitaka Y

The Journal of experimental medicine 20120213 3

Malignant mesothelioma (MM) is an incurable malignancy that is caused by exposure to asbestos and is accompanied by severe fibrosis. Because MM is usually diagnosed at an advanced stage and clinical identification of early lesions is difficult, its molecular pathogenesis has not been completely elucidated. Nearly 75% of MM cases have inactivating mutations in the NF2 (neurofibromatosis type 2; Merlin) gene or in downstream signaling molecules of the Hippo signaling cascade, which negatively regu ...[more]

PMID: 22329991

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