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Mouse mammary gland developmental programming by dietary exposure

ABSTRACT: Developmental effects of dietary fatty acids on murine mammary glands

ORGANISM(S): Mus musculus

SUBMITTER: Jeroen Pennings 

PROVIDER: E-TABM-1185 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Lasting effects on body weight and mammary gland gene expression in female mice upon early life exposure to n-3 but not n-6 high-fat diets.

Luijten Mirjam M   Singh Amar V AV   Bastian Caleb A CA   Westerman Anja A   Pisano M Michele MM   Pennings Jeroen L A JL   Verhoef Aart A   Green Maia L ML   Piersma Aldert H AH   de Vries Annemieke A   Knudsen Thomas B TB  

PloS one 20130207 2

Exposure to an imbalance of nutrients prior to conception and during critical developmental periods can have lasting consequences on physiological processes resulting in chronic diseases later in life. Developmental programming has been shown to involve structural and functional changes in important tissues. The aim of the present study was to investigate whether early life diet has a programming effect on the mammary gland. Wild-type mice were exposed from 2 weeks prior to conception to 6 weeks  ...[more]