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MicroRNA-expression profiling according to MN1 mRNA expression levels in de novo cytogenetically normal acute myeloid leukemia patients aged 60 years or older.

ABSTRACT: microRNA-expression profiling according to MN1 mRNA expression levels in de novo cytogenetically normal acute myeloid leukemia patients aged 60 years or older.

ORGANISM(S): Homo sapiens

SUBMITTER: Guido Marcucci

PROVIDER: E-TABM-1190 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene-expression profiling according to MN1 mRNA expression levels in de novo cytogenetically normal acute myeloid leukemia patients aged 60 years or older.

Project description:Gene-expression profiling according to MN1 mRNA expression levels in de novo cytogenetically normal acute myeloid leukemia patients aged 60 years or older.

2011-10-20 | E-TABM-1189 | biostudies-arrayexpress

microRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia patients 60 years.\//\<

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MicroRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia patients >=60 years.

Project description:MicroRNA-expression profiling according to the Wilms tumor 1 (WT1) single nucleotide polymorphism rs16754 in adult de novo cytogenetically normal acute myeloid leukemia patients >=60 years.

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Low expression of MN1 associates with better treatment response in older patients with de novo cytogenetically normal acute myeloid leukemia.

Project description:Low MN1 expression bestows favorable prognosis in younger adults with cytogenetically normal acute myeloid leukemia (CN-AML), but its prognostic significance in older patients is unknown. We analyzed pretherapy MN1 expression in 140 older (? 60 years) de novo CN-AML patients treated on cytarabine/daunorubicin-based protocols. Low MN1 expressers had higher complete remission (CR) rates (P = .001), and longer overall survival (P = .03) and event-free survival (EFS; P = .004). In multivariable models, low MN1 expression was associated with better CR rates and EFS. The impact of MN1 expression on overall survival and EFS was predominantly in patients 70 years of age or older, with low MN1 expressers with mutated NPM1 having the best outcome. The impact of MN1 expression was also observed in the Intermediate-I, but not the Favorable group of the European LeukemiaNet classification, where low MN1 expressers had CR rates and EFS similar to those of Favorable group patients. MN1 expresser-status-associated gene- and microRNA-expression signatures revealed underexpression of drug resistance and adverse outcome predictors, and overexpression of HOX genes and HOX-gene-embedded microRNAs in low MN1 expressers. We conclude that low MN1 expression confers better prognosis in older CN-AML patients and may refine the European LeukemiaNet classification. Biologic features associated with MN1 expression may help identify new treatment targets.

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Functional dissection of Bmi1 independence of MN1 leukemia

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MN1 or MN1-TEL in the promonocytic cell line U937

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