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Transcription profiling of fission yeast in response to changes in copper and iron levels

ABSTRACT: Recent studies in comparative genomics demonstrate that inter-species comparisons represent a powerful tool for revealing both conserved and specialized biological processes across large evolutionary distances. All cells need to adjust to environmental fluctuations in metal levels since both metal excess and deficit are detrimental. Here, we explore the conservation of metal homoeostasis in two distantly related yeasts, examining genome-wide gene expression responses to changing copper and iron levels in budding and fission yeast using DNA microarrays

INSTRUMENT(S): Axon GenePix 4000B scanning hardware

ORGANISM(S): Schizosaccharomyces pombe

SUBMITTER: Gabriella Rustici 

PROVIDER: E-TABM-120 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Global transcriptional responses of fission and budding yeast to changes in copper and iron levels: a comparative study.

Rustici Gabriella G   van Bakel Harm H   Lackner Daniel H DH   Holstege Frank C FC   Wijmenga Cisca C   Bähler Jürg J   Brazma Alvis A  

Genome biology 20070101 5

<h4>Background</h4>Recent studies in comparative genomics demonstrate that interspecies comparison represents a powerful tool for identifying both conserved and specialized biologic processes across large evolutionary distances. All cells must adjust to environmental fluctuations in metal levels, because levels that are too low or too high can be detrimental. Here we explore the conservation of metal homoeostasis in two distantly related yeasts.<h4>Results</h4>We examined genome-wide gene expres  ...[more]

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