Unknown,Transcriptomics,Genomics,Proteomics

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Deletion mutant analysis of established glucose signalling and metabolic pathway members in Saccharomyces cerevisiae.


ABSTRACT: Deletion mutants of all established glucose signalling and some metabolic pathway members have been analyzed by expression profiling. Tps2 double mutants are profiled to verify the prediction that Tps2 is one of the most downstream transcriptional components.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Patrick Kemmeren 

PROVIDER: E-TABM-1210 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator.

Gonzalez Deyarina D   Hamidi Nurul N   Del Sol Ricardo R   Benschop Joris J JJ   Nancy Thomas T   Li Chao C   Francis Lewis L   Tzouros Manuel M   Krijgsveld Jeroen J   Holstege Frank C P FC   Conlan R Steven RS  

Proceedings of the National Academy of Sciences of the United States of America 20140203 7


Mediator, an evolutionary conserved large multisubunit protein complex with a central role in regulating RNA polymerase II-transcribed genes, serves as a molecular switchboard at the interface between DNA binding transcription factors and the general transcription machinery. Mediator subunits include the Cdk8 module, which has both positive and negative effects on activator-dependent transcription through the activity of the cyclin-dependent kinase Cdk8, and the tail module, which is required fo  ...[more]

Publication: 1/2

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