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Transcription profiling of mouse beta cells after treatment with cycloheximide, glucose and chlorophenylthio-cAMP

ABSTRACT: Glucose-responsive genes in mouse beta cells

ORGANISM(S): Mus musculus

SUBMITTER: Celine Delucinge

PROVIDER: E-TABM-141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcriptional response of pancreatic beta cells to metabolic stimulation: large scale identification of immediate-early and secondary response genes.

Glauser Dominique A DA Brun Thierry T Gauthier Benoit R BR Schlegel Werner W

BMC molecular biology 20070622

<h4>Background</h4>Physiological long term adaptation of pancreatic beta cells is driven by stimuli such as glucose and incretin hormones acting via cAMP (e.g. GLP-1) and involves regulated gene expression. Several rapidly inducible immediate-early genes (IEGs) have been identified in beta cells. Many of these IEGs code for transcription factors and have the potential to control the transcription of downstream target genes likely involved in long term cellular adaptation. The identity of these t ...[more]

PMID: 17587450

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