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Dissection of a metastasis expression signature into stromal and tumor cell components for improved predictive accuracy and sample scope

ABSTRACT: Experiment performed to investigate the influence of different tumor percentages on a previously identified predictive signature for HNSCC metastasis.

ORGANISM(S): Homo sapiens

DISEASE(S): head and neck squamous cell carcinoma

SUBMITTER: Paul Roepman

PROVIDER: E-TABM-152 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dissection of a metastatic gene expression signature into distinct components.

Roepman Paul P de Koning Erica E van Leenen Dik D de Weger Roel A RA Kummer J Alain JA Slootweg Piet J PJ Holstege Frank C P FC

Genome biology 20060101 12

<h4>Background</h4>Metastasis, the process whereby cancer cells spread, is in part caused by an incompletely understood interplay between cancer cells and the surrounding stroma. Gene expression studies typically analyze samples containing tumor cells and stroma. Samples with less than 50% tumor cells are generally excluded, thereby reducing the number of patients that can benefit from clinically relevant signatures.<h4>Results</h4>For a head-neck squamous cell carcinoma (HNSCC) primary tumor ex ...[more]

PMID: 17156469

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